Activity of respiratory chain cytochrome complexes and cytochromes content in the rat kidney mitochondria under different nutrients content in a diet

An important role in ensuring the functioning of respiratory chain belongs to cytochrome part, which includes complexes III (ubiquinol-cytochrome c oxidoreductase) and IV (cytochrome oxidase). The key components these enzymatic are heme-containing cytochromes, number depends on balance heme synthesis catabolism. δ-Aminolevulinate synthase catalyzes first step biosynthetic pathway, while oxygenase is enzyme degradation. It known that nutritional imbalances drive many risk factors for chronic kidney disease. That why our research aimed study activity ubiquinol-cytochrome oxidoreductase oxidase complexes, level cytochromes a+a3, b, c, c1, enzymes metabolism mitochondria rat kidneys under conditions different content protein sucrose animal diet. obtained results showed a decreased reduced levels c1 nutrient imbalance, with most pronounced changes found animals kept low-protein/high-sucrose A decrease δ-aminolevulinate simultaneous 2-fold increase was diet compared those full-value indicating an intensification catabolism along inhibition its synthesis. testify energy imbalance turn can lead progression injury. Keywords: oxidase, oxygenase, nutrients, oxidoreductase,